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KMID : 0363420150290020037
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Journal of Korean Oriental Pediatrics
2015 Volume.29 No. 2 p.37 ~ p.48
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The Antiobese Effects of Gamikwakhyangjungkisan and Fermented GamiKwakhyangjungkisan in Preadipocytes and Mice Fed High Fat Diet
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Kim Ju-Hee
Park Eun-Jung
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Abstract
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Objectives: This experimental study was designed to investigate the antiobese effects of Gamikwakhyangjungkisan
and Fermented GamiKwakhyangjungkisan.
Methods: The cellular lipid contents were assessed by Oil-Red-O staining. The expression of PPARγ and C/EBPα
were determined by real time RT-PCR and western blotting. In addition, body weight gain and serum lipid levels were measured in the mice with obesity induced by the high fat-diet for four weeks.
Results: Gamikwakhyangjungkisan and Fermented GamiKwakhyangjungkisan is reduced 3T3-L1 cells’ differentiation
and the expressions of PPARγ and C/EBPα in high concentration group. High-fat diet + Fermented GamiKwakhyangjungkisan group significantly reduced body weight gain. High-fat diet + Fermented
GamiKwakhyangjungkisan group significantly increased HDL-cholesterol contents and reduced LDL-cholesterol contents. Furthermore, Fermented GamiKwakhyangjungkisan is excellent antiobese effects than Gamikwakhyangjungkisan.
Conclusions: These results demonstrate that Gamikwakhyangjungkisan and Fermented GamiKwakhyangjungkisan exerts antiobese effect in 3T3-L1 cells and mice fed high fat diet. Furthermore, Fermented GamiKwakhyangjungkisan is excellent antiobese effects than Gamikwakhyangjungkisan.
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KEYWORD
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GamiKwakhyangjungkisan, Fermented, Obesity, 3T3-L1 cell, Adipocyte differentiation, PPARγ, C/EBPα, Serum lipid
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